Manhattan Transfer is an American novel by John Dos Passos published in 1925. It focuses on the development of urban life in New York City from the Gilded Age to the Jazz Age as told through a series of overlapping individual stories. It is considered to be one of Dos Passos' most important works.

The book attacks the consumerism and social indifference of contemporary urban life, portraying a Manhattan that is merciless yet teeming with energy and restlessness. The book shows some of Dos Passos' experimental writing techniques and narrative collages that would become more pronounced in his U.S.A. trilogy and other later works.

Manhattan Transfer entered the public domain in 2021.